It happened at the back of the “Club of Life” in London Street between half past midnight and 1am on Saturday Feb 22.
A 28 year old local man intervened in an altercation outside the club. He then got hit in the mouth with a bottle.
The woman who hit him is described as in her 30s with long dark hair.
PC Jenny Carr at Andover would like to hear from any witnesses, contact her on 101 or via Crimestoppers anonymously on 0800 555 111.